Charming 2BR/2BA 1,456sq. ft. main home with a detached 450 sq. ft.guest/in-law suite on over an acre in desirable Santa Fe River Plantations. Beautiful large oaks frame the front yard with peaceful views overlooking the neighboring farm, while the spacious backyard is completely fenced. Inside, the home features an open split floor plan, fresh paint throughout, indoor laundry room, and French doors leading to the screened lanai. The kitchen includes stainless steel appliances. The spacious primary bedroom offers two walk-in closets, while the remodeled primary bath features quartz countertops, wood-look tile flooring, and a tiled walk-in shower. The home has been completely repiped and also features a metal roof(2015). The detached guest/in-law suite includes a closet, sink, half bath, and window A/C unit—perfect for guests, a home office, or additional flex space. A new metal building provides a 24' x 25' enclosed garage plus a 20' x 24' open carport, offering excellent space for vehicles, boats, equipment, or a workshop. Located just over the Columbia County line with lower property taxes and approximately 25 minutes to Gainesville, this property offers a peaceful country setting close to North Florida's springs, rivers, state parks, boating, fishing, equestrian trails, and nearby High Springs.